Explore the collaborative relationship between Wnt/β-catenin and KRAS pathways in driving colorectal cancer development and progression.
Explore how targeting the SPHK1/HIF1 pathway offers new hope for eliminating colorectal cancer stem cells and overcoming treatment resistance.
Discover how homoharringtonine targets the NKD1/PCM1 pathway to fight colorectal cancer through novel molecular mechanisms.
Discover how LEDGF/p75 protein collaborates with MSI and KRAS mutations to drive colorectal cancer progression in this groundbreaking study.
Discover how EZH2 inhibition unexpectedly enhances PD-L1 protein stability through USP22-mediated deubiquitination in colorectal cancer, revealing new therapeutic strategies.
Discover how UBE2N and PSME3 proteins serve as potential biomarkers for early colorectal cancer detection through advanced proteomic analysis.
Discover how the MEK/ERK-ZEB1-USP10 pathway controls colorectal cancer metastasis and the therapeutic implications of this molecular switch.